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Before a widespread adoption of the kidney ageing terminology by health professionals, the researchers call for further discussion with patient groups and broader studies of kidney decline across different populations and ethnic groups to better understand the link between kidney health and ageing. CMAJ Doi: Professor Trish Greenhalgh launches a highly applied course to translate research findings into practical application. Salman Waqar. With significant recent announcements poised to affect the future of British general practice, GP academic trainee Dr Salman Waqar reflects on his visit to the Netherlands on an exchange program to see if the grass was greener on the other side.
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The authors also found that GAPR-1, a cellular protein that associates with the Golgi, binds the same domain of beclin-1 to inhibit autophagy. This peptide decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens including HIV-1 in vitro , and reduces mortality in mice infected with chikungunya or West Nile virus. In addition, autophagy is a surveillance sensor for kidney cells, and is upregulated by stress stimuli such as ischemia and nephrotoxins.
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Autophagy thereby counteracts kidney disease by eliminating damaged organelles or supplying energy. Although the precise mechanism of the renoprotective role of autophagy remains to be elucidated, strategies aimed at modulating autophagy hold promise for treating kidney disease.
Physiological and pathological roles of autophagy in the kidney.
Basal autophagy potently coordinates cellular homeostasis in the kidney, particularly in podocytes and proximal tubular cells, thereby allowing cell-specific function and slowing kidney aging. In addition, autophagy is upregulated by stress stimuli such as ischemia and nephrotoxins. Autophagy thereby counteracts kidney disease. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.
Sign In or Create an Account. Sign In. Advanced Search. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents. Autophagy and the kidney: health and disease Yoshitsugu Takabatake. Correspondence and offprint requests to: Yoshitaka Isaka; E-mail: isaka kid. Oxford Academic. Google Scholar. Tomonori Kimura. Atsushi Takahashi. Yoshitaka Isaka.
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Cite Citation. Permissions Icon Permissions. Abstract Macroautophagy is a highly evolutionally conserved degradation process by which cytosolic materials including macromolecules such as proteins and lipids and damaged organelles are broken down to their basic components. Open in new tab Download slide.
Search ADS. Eating the strangers within: host control of intracellular bacteria via xenophagy. Guidelines for the use and interpretation of assays for monitoring autophagy.
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Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis. Autophagy in the heart and liver during normal aging and calorie restriction. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.
'Kidney age', not kidney disease — Nuffield Department of Primary Care Health Sciences
Studies on induced cellular autophagy. Electron microscopy of cells with in vivo labelled lysosomes. Two types of autophagy in the podocytes in renal biopsy specimens: ultrastructural study. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. Autophagy protects the proximal tubule from degeneration and acute ischemic injury. Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia—reperfusion injury.
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Cerebral ischemia—hypoxia induces intravascular coagulation and autophagy.
The mitochondrial permeability transition initiates autophagy in rat hepatocytes. Recent advances in understanding the biochemical and molecular mechanism of diabetic nephropathy. Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. Role of the energy sensor AMP-activated protein kinase in renal physiology and disease.
The global burden of kidney disease and the sustainable development goals
Inhibition of cellular autophagy in proximal tubular cells of the kidney in streptozotocin-diabetic and uninephrectomized rats. Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat. Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress. A morphometric study of cellular autophagy including diurnal variations in kidney tubules of normal rats.
Mitochondrial autophagy promotes cellular injury in nephropathic cystinosis. Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury. Spatiotemporally controlled induction of autophagy-mediated lysosome turnover. Chemical modulators of autophagy as biological probes and potential therapeutics. Autophagy modulation as a potential therapeutic target for diverse diseases.
Sirolimus and kidney growth in autosomal dominant polycystic kidney disease. All rights reserved. Issue Section:. Download all figures.
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